Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: Effects of progesterone administration
Neuropathic pain elicited by spinal cord injury (SCI) is refractory to treatment. SCI induces changes in the spinal expression of Galanin, NPY and their receptors. These neuropeptide systems may be involved in an endogenous protective response. Progesterone (PG) prevents the injury-induced changes in neuropeptide expression. PG prevents allodynia and emerges as an attractive strategy to prevent chronic pain.