Distinct inflammatory responses differentiate cerebral infarct from transient ischaemic attack

详细信息    查看全文

• 作者：Christopher W.L. Armstrong^a ; Erika Bosio^b ; ^c ; ^{erika.bosio@uwa.edu.au} ; Claire Neil^b ; ^c ; Simon G.A. Brown^a ; ^b ; ^c ; Graeme J. Hankey^d ; Daniel M. Fatovich^a ; ^b ; ^c
• 关键词：Granzyme B ; Inflammatory markers ; MMP-9 ; Neutrophils ; S100A12 ; Stroke
• 刊名：Journal of Clinical Neuroscience
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：35
• 期：Complete
• 页码：97-103
• 全文大小：854 K
• 卷排序：35

文摘

Infarct and haemorrhage show neutrophilia, transient ischaemic attack (TIA) does not. In infarct, Granzyme B (GzmB) expression is downregulated while matrix metalloproteinase 9 (MMP-9) and S100A12 increase. Infarct shows increases in circulating MMP-9 and S100A12, while TIA does not. GzmB accumulates intracellularly during stroke and is not released. Different mechanisms underlie TIA and infarct.