Association Between Platelet Function and Disc Hemorrhage in Patients With Normal-Tension Glaucoma: A Prospective Cross-Sectional Study

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• 作者：Seong Hee Shim^aAuthor Vitae ; Joon Mo Kim^a ; ^{joonmo1.kim@samsung.com" class="auth_mail" title="E-mail the corresponding author} ; Hee-Yeon Woo^b ; Ko Un Shin^a ; Jae Woong Koh^c ; Ki Ho Park^d
• 刊名：American Journal of Ophthalmology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：160
• 期：6
• 页码：1191-1199.e1
• 全文大小：546 K

文摘

To evaluate the association between platelet function and disc hemorrhage in patients with normal-tension glaucoma.

Design

Prospective, cross-sectional study.

Methods

Study involved a total of 315 subjects, including patients with normal-tension glaucoma and disc hemorrhage (n = 120), patients with normal-tension glaucoma without disc hemorrhage (n = 75), and healthy individuals (control group, n = 120). A detailed eye examination including visual field testing, color disc photography, optical coherence tomography scanning, and measurement of collagen/epinephrine closure time using a platelet function analyzer were performed for all subjects.

Results

The collagen/epinephrine closure time (s) as measured by the platelet function analyzer was approximately 14%–24% longer in the normal-tension glaucoma and disc hemorrhage group compared with the other groups (141.92 ± 53.44 [with normal-tension glaucoma and disc hemorrhage] vs 124.60 ± 46.72 [with normal-tension glaucoma without disc hemorrhage] vs 114.84 ± 34.84 [healthy individuals], 1-way analysis of variance test, P < .001). The activated partial thromboplastin time (s) value of the normal-tension glaucoma with disc hemorrhage group was also higher than the control group. Stepwise multiple logistic regression analysis revealed that only a longer collagen/epinephrine closure time (OR adjusted for age, sex, prothrombin time, activated partial thromboplastin time, diabetes mellitus, hypertension, hypotension, heart disease, hypothyroidism, migraine, stroke, hypercholesterolemia: 2.94; 95% CI: 1.40–6.17) was independently associated with disc hemorrhage. A similar trend was observed when platelet function was compared among the 3 groups with respect to age.

Conclusions

Our results suggest that platelet function is significantly associated with disc hemorrhage in patients with normal-tension glaucoma. Delayed absorption resulted from prolonged bleeding due to delayed platelet aggregation may have an effect on the detectability of disc hemorrhage in patients with normal-tension glaucoma.