Cytotoxic quassinoids from Ailanthus altissima

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• 作者：Yan Wang^a ; ^b ; ^&dagger ; ; Wen-Jing Wang^a ; ^b ; ^&dagger ; ; Chang Su^a ; ^b ; Dong-Mei Zhang^a ; ^b ; Li-Peng Xu^a ; Rong-Rong He^a ; ^b ; Lei Wang^a ; ^b ; Jian Zhang^a ; ^b ; Xiao-Qi Zhang^a ; ^b ; ^{xqzhang7401@yahoo.com.cn} ; Wen-Cai Ye^a ; ^b ; ^{chywc@yahoo.com.cn}
• 关键词：Ailanthus altissima ; Simaroubaceae ; Quassinoids ; Cytotoxicity
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：1 February, 2013
• 年：2013
• 卷：23
• 期：3
• 页码：654-657
• 全文大小：394 K

文摘

Two new quassinoids, altissinol A (1) and B (7), together with 12 known quassinoids, were isolated from the 95 % ethanol extract of the barks of Ailanthus altissima. The structures of the new compounds (1 and 7) were determined on the basis of the spectroscopic methods including UV, IR, HR-ESI-MS, 1D and 2D NMR. The cytotoxic potential of all isolates were evaluated in vitro against three human hepatoma cell lines. Quassinoids 1-7 displayed potent cytotoxic activities against human hepatoma Hep3B and HepG2 cell lines. Interestingly, compounds 2, 3, and 5 exhibited cytotoxic activity against multidrug resistance HepG2/ADM cell line with IC₅₀ value 4.3-fold more sensitive to Doxorubicin (DOX).