GAPDH binds to a conserved region in the 3′ UTRs of SCN1A and SCN3A genes. The binding of GAPDH to the conserved element alters gene expression. GAPDH mediates abnormal expressions of Scn1a and Scn3a under seizure condition. KD or BHB treament rescues abnormal expressions of Scn1a and Scn3a via GADPH.