Sepsis-induced impairment of neutrophil chemotaxis on a microfluidic chip
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- 作者：Xiaoguang Lua ; dllxg@126.com" class="auth_mail" title="E-mail the corresponding author ; Chang Lvb ; Yueyang Quc ; Yong Luoc ; Bingcheng Lind ; Libin Zhane ; Yi Songa ; Zhiwei Fana
- 关键词：Neutrophil chemotaxis ; Sepsis ; TLR2 ; CXCR2 ; TLR2-CXCR2 pathway ; Microfluidic chip
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：173
- 期：Complete
- 页码：55-60
- 全文大小：1657 K
文摘
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Neutrophil chemotaxis could be used as a diagnostic index of septic severity and an effective means for septic treatment and prognosis.
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Neutrophil chemotaxis in sepsis was significantly reduced as compared to healthy individuals.
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We speculated that impaired neutrophil chemotaxis in sepsis was probably mediated by the TLR2-CXCR2 pathway.