The Distance Between Donor and Acceptor Affects the Proportion of C1′ and C2′ Oxidation Products of DNA in a BrU-Containing Excess Electron Transfer System

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• 作者：Ryu Tashiro ; Akimichi Ohtsuki ; Hiroshi Sugiyama
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：October 20, 2010
• 年：2010
• 卷：132
• 期：41
• 页码：14361-14363
• 全文大小：223K
• 年卷期：v.132,no.41(October 20, 2010)
• ISSN：1520-5126

文摘

We have investigated the products of ^BrU in excess electron transfer and have demonstrated that in DNA the proportion of products changes with the distance between the donor and acceptor. On the basis of a labeling experiment using H₂¹⁸O, we have shown that hole migration from Py^•+ formed after charge separation is involved in the reaction.