New Palladium(II) and Platinum(II) Complexes with 9-Aminoacridine: Structures, Luminiscence, Theoretical Calculations, and Antitumor Activity

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• 作者：JoseL9 ; Ruiz ; Julia Lorenzo ; Consuelo Vicente ; Gregorio LoL9 ; pez ; JoseL9 ; MariL9 ; a LoL9 ; pez-de-Luzuriaga ; Miguel Monge ; Francesc X. AvileL9 ; s ; Delia Bautista ; Virtudes Moreno ; Antoni
• 刊名：Inorganic Chemistry
• 出版年：2008
• 出版时间：August 4, 2008
• 年：2008
• 卷：47
• 期：15
• 页码：6990-7001
• 全文大小：500K
• 年卷期：v.47,no.15(August 4, 2008)
• ISSN：1520-510X

文摘

The new complexes [Pd(dmba)(N10-9AA)(PPh₃)]ClO₄ (1), [Pt(dmba)(N9-9AA)(PPh₃)]ClO₄ (2), [Pd(dmba)(N10-9AA)Cl] (3), and [Pd(C₆F₅)(N10-9AA)(PPh₃)Cl] (4) (9-AA = 9-aminoacridine; dmba = N,C-chelating 2-(dimethylaminomethyl)phenyl) have been prepared. The crystal structures have been established by X-ray diffraction. In complex 2, an anagostic C−H···Pt interaction is observed. All complexes are luminescent in the solid state at room temperature, showing important differences between the palladium and platinum complexes. Complex 2 shows two structured emission bands at high and low energies in the solid state, and the lifetimes are in agreement with excited states of triplet parentage. Density functional theory and time-dependent density functional theory calculations for complex 2 have been done. Values of IC₅₀ were also calculated for the new complexes 1−4 against the tumor cell line HL-60. All of the new complexes were more active than cisplatin (up to 30-fold in some cases). The DNA adduct formation of the new complexes synthesized was followed by circular dichroism and electrophoretic mobility. Atomic force microscopy images of the modifications caused by the complexes on plasmid DNA pBR322 were also obtained.