The Formal [4+3] Cycloaddition between Donor鈭扐cceptor Cyclobutanes and Nitrones

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• 作者：Andrew C. Stevens ; Cory Palmer ; Brian L. Pagenkopf
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：March 18, 2011
• 年：2011
• 卷：13
• 期：6
• 页码：1528-1531
• 全文大小：772K
• 年卷期：v.13,no.6(March 18, 2011)
• ISSN：1523-7052

文摘

The formal [4+3] cycloaddition of 2-alkoxy-1,1-dicarboxylate activated donor鈭抋cceptor cyclobutanes with nitrones is disclosed. The reaction forms structurally unique oxazepines in moderate to high yield with a wide scope of nitrones. In most cases either a diastereomeric mixture or a single diastereomer may be formed, depending on the reaction conditions.