Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies

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• 作者：Bartholomäus Pieber ; C. Oliver Kappe
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：18
• 期：5
• 页码：1076-1079
• 全文大小：361K
• ISSN：1523-7052

文摘

A continuous process for the synthesis and inline separation of anhydrous trifluoromethyl diazomethane in a single continuous flow process is presented. The diazo building block is generated from the corresponding amine and NaNO<sub>2sub> under acidic, aqueous conditions and subsequently diffuses through a gas-permeable membrane into an organic stream. To avoid storage and transportation of the hazardous compound, a representative downstream process in a packed-bed reactor yielding highly functionalized building blocks was developed.