Direct Access to Enantiomerically Enriched -Amino Phosphonic Acid Derivatives by Organocatalytic Asymmetric Hydrophosphonylation of

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• 作者：Daniel Pettersen ; Mauro Marcolini ; Luca Bernardi ; Francesco Fini ; Raquel P. Herrera ; Valentina Sgarzani ; Alfredo Ricci
• 刊名：Journal of Organic Chemistry
• 出版年：2006
• 出版时间：August 4, 2006
• 年：2006
• 卷：71
• 期：16
• 页码：6269 - 6272
• 全文大小：64K
• 年卷期：v.71,no.16(August 4, 2006)
• ISSN：1520-6904

文摘

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A simple and efficient organocatalytic enantioselectivehydrophosphonylation of imines to enantiomerically enriched-amino phosphonates is reported. By using 10 mol % ofquinine as the catalyst in the enantioselective addition ofdiethyl phosphite to N-Boc protected imines, -aminophosphonates are obtained in moderate to good yields andwith up to 94% ee.