Gadolinium Chelate Coated Gold Nanoparticles As Contrast Agents for Both X-ray Computed Tomography and Magnetic Resonance Imaging
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- 作者：Christophe Alric ; Jacqueline Taleb ; Gé ; raldine Le Duc ; Cé ; line Mandon ; Claire Billotey ; Alice Le Meur-Herland ; Thierry Brochard ; Francis Vocanson ; Marc Janier ; Pascal Perriat ; Sté ; phane Ro
- 刊名：Journal of the American Chemical Society
- 出版年：2008
- 出版时间：May 7, 2008
- 年：2008
- 卷：130
- 期：18
- 页码：5908 - 5915
- 全文大小：1587K
- 年卷期：v.130,no.18(May 7, 2008)
- ISSN：1520-5126
文摘
Functionalized gold nanoparticles were applied as contrast agents for both in vivo X-ray and magnetic resonance imaging. These particles were obtained by encapsulating gold cores within a multilayered organic shell which is composed of gadolinium chelates bound to each other through disulfide bonds. The contrast enhancement in MRI stems from the presence of gadolinium ions which are entrapped in the organic shell, whereas the gold core provides a strong X-ray absorption. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in the lungs, spleen, and liver.