FIGR ID=jo060976fn00001>figures/jo060976fn00001.gif" ALIGN="left" HSPACE=5> |
Kahalali
de compounds are pepti
des that are isolated
from a Hawaiian herbivorous marine species o
fmollusc,
Elysia rufescens, and its diet, the green alga
Bryopsis sp
. Kahalali
de F and its synthetic analoguesare the most promising compounds o
f the Kahalali
de family because they show antitumoral activity.Linear solid-phase syntheses o
f Kahalali
de F have been reported. Here we
describe several new improvedsynthetic routes based on convergent approaches with distinct orthogonal protection schemes
for thepreparation o
f Kahaladi
de analogues. These strategies allow a better control and characterization o
f theintermediates because more reactions are per
formed in solution.