Phloroglucinols with Prooxidant Activity from Garcinia subelliptica

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• 作者：Chien-Chang Wu ; Yi-Huang Lu ; Bai-Luh Wei ; Shyh-Chyun Yang ; Shen-Jen Won ; Chun-Nan Lin
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：February 2008
• 年：2008
• 卷：71
• 期：2
• 页码：246 - 250
• 全文大小：496K
• 年卷期：v.71,no.2(February 2008)
• ISSN：1520-6025

文摘

A new phloroglucinol, garcinielliptone HF (1), possessing an unprecedented skeleton, and the tautomeric pair of garcinielliptone FC (2/2a) were isolated from the heartwood and pericarp of Garcinia subelliptica, respectively. Their structures, including relative configurations, were elucidated by means of spectroscopic methods. The ability of compounds 1 and 2/2a to induce DNA-cleavage activity was examined using supercoiled plasmid pBR322 DNA. In the presence of Cu(II), compounds 1 and 2/2a caused significant breakage of pBR322 DNA. The involvement of H₂O₂ and O₂^•−, and H₂O₂, O₂^•−, and OH^• in 1- and 2/2a-mediated scission, respectively, was established by inhibition or no protection of DNA breakage by various oxygen radical scavengers. Thus, in the presence Cu(II), 1 and 2/2a may show a prooxidant effect on DNA and induce cell death.