Cipacinoids A–D, Four Limonoids with Spirocyclic Skeletons from Cipadessa cinerascens

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• 作者：Jin-Hai Yu ; Qun-Fang Liu ; Li Sheng ; Guo-Cai Wang ; Jia Li ; Jian-Min Yue
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：February 5, 2016
• 年：2016
• 卷：18
• 期：3
• 页码：444-447
• 全文大小：309K
• ISSN：1523-7052

文摘

Four limonoids, cipacinoids A–D (1–4), with spirocyclic skeletons were isolated from Cipadessa cinerascens. It is particularly notable that compounds 1–3 had a 17S-configuration for the first time in the limonoid family. Their structures with absolute configurations were assigned by spectroscopic data, X-ray crystallography, and CD analysis. Compound 1 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibition.