文摘
The present study developed an improved analytical method for simultaneous quantification of seven neonicotinoids in food by ultraperformance liquid chromatography combined with electrospray ionization triple quadrupole tandem mass spectrometry (UPLC−MS/MS) under the multiple reaction monitoring (MRM) mode. The optimization of extraction, cleanup, UPLC separation and MS/MS parameters of analytes were especially focused on. The low limits of quantification (LOQs) of neonicotinoids ranged from 0.1 to 6 μg kg−1. Meanwhile, reasonable recoveries (65−120%) of seven neonicotinoids for food including apple, cabbage, potato, rice, tea, milk, chicken, pork and egg were demonstrated in different spiked levels within their respective linear range (0.025−150 μg kg−1). The developed analytical method would be appropriate for the routine, high throughput, high sensitivity quantification of seven neonicotinoids using simple sample pretreatment.