文摘
Normal and two transformed buccal keratinocyte lines were cultured under a standardized conditionto explore mechanisms of carcinogenesis and tumor marker expression at transcript and protein levels.An approach combining three bioinformatic programs allowed coupling of abundant proteins and large-scale transcript data to low-abundance transcriptional regulators. The analysis identified previouslyproposed and suggested novel protein biomarkers, gene ontology categories, molecular networks, andfunctionally impaired key regulator genes for buccal/oral carcinoma.