Effects of Oleic Acid Rich Oils on Aorta Lipids and Lipoprotein Lipase Activity of Spontaneously Hypertensive Rats

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• 作者：Javier S. Perona ; Rosal&iacute ; a Rodr&iacute ; guez-Rodr&iacute ; guez ; and Valentina Ruiz-Gutierrez
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2005
• 出版时间：September 7, 2005
• 年：2005
• 卷：53
• 期：18
• 页码：7330 - 7336
• 全文大小：115K
• 年卷期：v.53,no.18(September 7, 2005)
• ISSN：1520-5118

文摘

Hypertension development in the spontaneously hypertensive rat (SHR) leads to vascular wall wideningby smooth muscle cell proliferation. In these cells, triglycerides (TG) and cholesteryl esters (CE) canaccumulate until they become foam cells. We administrated two oleic rich oils, virgin olive (VOO)and high oleic sunflower oils (HOSO), to Wistar-Kyoto rats (WKY) and SHR because these oilshave been reported to reduce the risk for coronary heart disease in hypertensive patients and SHR.After 12 weeks of feeding, we analyzed the TG and CE composition and the lipolytic (lipoproteinlipase, LPL, and non-LPL) activity in aortas of these animals. HOSO increased the content of linoleicacid in CE and TG of aortas from both WKY and SHR as compared with animals fed VOO byproportionally decreasing the content of oleic acid. Conversely, VOO reduced the LPL and non-LPLlipolytic activities, hence limiting the free fatty acids available for the synthesis of TG and CE in thevascular wall.Keywords: SHR; aorta; triglyceride; cholesteryl ester; LPL