Aerosol-Based Fabrication of Biocompatible Organic鈥揑norganic Nanocomposites
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- 作者：Jeong Hoon Byeon ; Jeffrey T. Roberts
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2012
- 出版时间：May 23, 2012
- 年：2012
- 卷：4
- 期：5
- 页码：2693-2698
- 全文大小：424K
- 年卷期：v.4,no.5(May 23, 2012)
- ISSN：1944-8252
文摘
Several novel nanoparticle composites were conveniently obtained by appropriately reacting freshly produced aerosol metal nanoparticles with soluble organic components. A serial reactor consisting of a spark particle generator coupled to a collison atomizer was used to fabricate the new materials, which included nanomagnetosols (comprising iron nanoparticles, the drug ketoprofen, and a Eudragit shell), hybrid nanogels (comprising iron nanoparticles and an N-isopropylacrylamide, NIPAM, gel), and nanoinorganics (gold immobilized silica). A fourth hybrid material, consisting of iron鈥揼old nanoparticles and NIPAM) was obtained via an aerosol into liquid configuration, in which aerosol iron鈥揼old particles were collected into a NIPAM/ethanol solution and then formed into nanogels with NIPAM under ultrasonic treatment. The strategy outlined in this work is potentially generalizable as a new platform for creating biocompatible nanocomposites, using only clinically approved starting materials in a single pass and under low-temperature conditions.