Molecular Nanofibers of Olsalazine Form Supramolecular Hydrogels for Reductive Release of an Anti-inflammatory Agent
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  • 作者:Xinming Li ; Jiayang Li ; Yuan Gao ; Yi Kuang ; Junfeng Shi ; Bing Xu
  • 刊名:Journal of the American Chemical Society
  • 出版年:2010
  • 出版时间:December 22, 2010
  • 年:2010
  • 卷:132
  • 期:50
  • 页码:17707-17709
  • 全文大小:208K
  • 年卷期:v.132,no.50(December 22, 2010)
  • ISSN:1520-5126
文摘
Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the anti-inflammatory agent. This methodology will ultimately lead to new biomaterials for site-specific drug delivery.

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