Hydration of Drug−DNA Complexes: Greater Water Uptake for Adriamycin Compared to Daunomycin

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• 作者：Haijia Yu ; Jinsong Ren ; Jonathan B. Chaires ; Xiaogang Qu
• 刊名：Journal of Medicinal Chemistry
• 出版年：2008
• 出版时间：October 9, 2008
• 年：2008
• 卷：51
• 期：19
• 页码：5909-5911
• 全文大小：114K
• 年卷期：v.51,no.19(October 9, 2008)
• ISSN：1520-4804

文摘

Water is an integral part of DNA, and the conserved water molecules at the binding sites can modulate drug binding to DNA or protein. We report here that anthracycline antitumor antibiotics, adriamycin (AM) and daunomycin (DM), binding to DNA is accompanied by different hydration changes, with AM binding resulting in the uptake of about twice as many water molecules as DM. These results indicate that water is playing an important role in drug binding to DNA.