Fusarisetin A, an Acinar Morphogenesis Inhibitor from a Soil Fungus, Fusarium sp. FN080326
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- 作者：Jae-Hyuk Jang ; Yukihiro Asami ; Jun-Pil Jang ; Sun-Ok Kim ; Dong Oh Moon ; Kee-Sun Shin ; Daisuke Hashizume ; Makoto Muroi ; Tamio Saito ; Hyuncheol Oh ; Bo Yeon Kim ; Hiroyuki Osada ; Jong Seog Ahn
- 刊名：Journal of the American Chemical Society
- 出版年：2011
- 出版时间：May 11, 2011
- 年：2011
- 卷：133
- 期：18
- 页码：6865-6867
- 全文大小：747K
- 年卷期：v.133,no.18(May 11, 2011)
- ISSN：1520-5126
文摘
An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay system. The structure of 1 was determined in detail by NMR and circular dichroism spectroscopy, X-ray analysis, and chemical reaction experiments.