Theoretical Investigation of the Rubicordifolin Cascade

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• 作者：Jean-Philip Lumb ; Jamin L. Krinsky ; Dirk Trauner
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：November 19, 2010
• 年：2010
• 卷：12
• 期：22
• 页码：5162-5165
• 全文大小：252K
• 年卷期：v.12,no.22(November 19, 2010)
• ISSN：1523-7052

文摘

The results of a theoretical investigation on the complex cascade reaction leading to the natural product rubicordifolin are reported. These computations analyze the discrete transformations that are required during the conversion of the vinyl naphthoquinone starting material into the natural product, including two pseudopericyclic cyclizations as well as a diastereoselective, hetero-Diels−Alder reaction.