Radical (Phenylsulfonyl)difluoromethylation with Iododifluoromethyl Phenyl Sulfone

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• 作者：Ya Li ; Jun Liu ; Laijun Zhang ; Lingui Zhu ; Jinbo Hu
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：July 20, 2007
• 年：2007
• 卷：72
• 期：15
• 页码：5824 - 5827
• 全文大小：64K
• 年卷期：v.72,no.15(July 20, 2007)
• ISSN：1520-6904

文摘

An unprecedented radical (phenylsulfonyl)difluoromethylation of terminal alkenes with PhSO₂CF₂I has been achievedby using Et₃B/air as an initiator. This synthetic methodologywas also used in the one-pot regioselective preparation ofPhSO₂CF₂-substituted alkanes, and in the regio- and stereoselective preparation of PhSO₂CF₂-substituted alkenes withhigh E/Z ratio (up to 100:1).