Catalytic Asymmetric Cyclopropanation of Enones with Dimethyloxosulfonium Methylide Promoted by a La-Li3-(Biphenyldiolate)3 + NaI Complex

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• 作者：Hiroyuki Kakei ; Toshihiko Sone ; Yoshihiro Sohtome ; Shigeki Matsunaga ; Masakatsu Shibasaki
• 刊名：Journal of the American Chemical Society
• 出版年：2007
• 出版时间：November 7, 2007
• 年：2007
• 卷：129
• 期：44
• 页码：13410 - 13411
• 全文大小：50K
• 年卷期：v.129,no.44(November 7, 2007)
• ISSN：1520-5126

文摘

Catalytic asymmetric cyclopropanation of enones with dimethyloxosulfonium methylide using a La-Li₃-(biphenyldiolate)₃ + NaI complex is described. The present method is complementary to the previously reported catalytic enantioselective methods in terms of ylides used, and trans products were exclusively obtained in good yield (96-73%) and high enantioselectivity (99-84% ee). Use of biphenyldiol 1b-H₂ and NaI additive was essential to achieve high enantioselectivity.