Domino C–F Bond Activation of the CF3 Group: Synthesis of Fluorinated Dibenzo[a,c][7]annulenes from 2-(Trifluoromethyl)-1-alkenes and 2,2′-Diceriobiaryls
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- 作者：Takeshi Fujita ; Marina Takazawa ; Kazuki Sugiyama ; Naoto Suzuki ; Junji Ichikawa
- 刊名：Organic Letters
- 出版年：2017
- 出版时间：February 3, 2017
- 年：2017
- 卷：19
- 期：3
- 页码：588-591
- 全文大小：327K
- ISSN：1523-7052
文摘
The construction of ring-fluorinated seven-membered carbocycles was readily achieved via the domino SN2′-type/SNV reaction between 2-(trifluoromethyl)-1-alkenes and 1,4-carbodianions. The SN2′-type reaction of 2-(trifluoromethyl)-1-alkenes with 2,2′-diceriobiaryls generated the intermediary 1,1-difluoro-1-alkenes bearing a monoceriobiaryl moiety, which in turn underwent intramolecular SNV reaction to afford fluorinated 5H-dibenzo[a,c][7]annulenes.