Palladium-Catalyzed Approach to Primary Amides Using Nongaseous Precursors

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• 作者：Dennis U. Nielsen ; Rolf H. Taaning ; Anders T. Lindhardt ; Thomas M. G酶gsig ; Troels Skrydstrup
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：August 19, 2011
• 年：2011
• 卷：13
• 期：16
• 页码：4454-4457
• 全文大小：743K
• 年卷期：v.13,no.16(August 19, 2011)
• ISSN：1523-7052

文摘

A simple protocol is reported for the preparation of primary aryl amides under Pd-catalyzed carbonylation chemistry applying a two-chamber system with crystalline and nontransition metal based sources of carbon monoxide and ammonia. The method is suitable for the synthesis of a number of primary amides with good functional group tolerance. Incorporation of up>13up>CO into the primary amide group was also found to be effective making this approach useful for accessing carbon isotope labeled derivatives.