A Sonogashira Cross-Coupling/5-exo-dig Cyclization/Ionic Hydrogenation Sequence: Synthesis of 4-Substituted 3-Azabicyclo[3.1.0]hexan-2-ones from 2-Iodocyclopropanecarboxamides

详细信息    查看全文

• 作者：Beno卯t de Carn茅-Carnavalet ; Christophe Meyer ; Janine Cossy ; Beno卯t Foll茅as ; Jean-Louis Brayer ; Jean-Pierre Demoute
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：June 7, 2013
• 年：2013
• 卷：78
• 期：11
• 页码：5794-5799
• 全文大小：357K
• 年卷期：v.78,no.11(June 7, 2013)
• ISSN：1520-6904

文摘

A variety of 4-substituted 3-azabicyclo[3.1.0]hexan-2-ones have been prepared from 2-iodocyclopropanecarboxamides by a three-step sequence involving a copper-free Sonogashira coupling with terminal aryl- or heteroarylalkynes, followed by a 5-exo-dig cyclization and an ionic hydrogenation.