Selecting the Desired Solid Form by Membrane Crystallizers: Crystals or Cocrystals
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- 作者：Antonella Caridi ; Gianluca Di Profio ; Rocco Caliandro ; Antonietta Guagliardi ; Efrem Curcio ; Enrico Drioli
- 刊名：Crystal Growth & Design
- 出版年：2012
- 出版时间：September 5, 2012
- 年：2012
- 卷：12
- 期：9
- 页码：4349-4356
- 全文大小：380K
- 年卷期：v.12,no.9(September 5, 2012)
- ISSN：1528-7505
文摘
This work aims to describe a systematic study on the conditions promoting the selective formation of carbamazepine-saccharin cocrystals or single component crystals from water/ethanol solvent mixtures, by using a membrane crystallization process. Results revealed the ability to operate in the proper zone of the phase diagram of the system when opportunely choosing the initial solution conditions and limiting the maximum level of supersaturation by using the membrane-based technology. Control in the selective crystallization of a specific solid form can be achieved by adjusting the solvent evaporation through the micropores of the membrane. Furthermore, the direct correlation between transmembrane flow and polymorphic composition in the case of carbamazepine precipitation confirmed the possibility to produce particular metastable phases upon increasing the supersaturation rate.