Reversal of Tetracycline Resistance in Escherichia coli by Noncytotoxic bis(Tryptophan)s
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- 作者：Joseph W. Meisel ; Mohit B. Patel ; Evan Garrad ; Ryan A. Stanton ; George W. Gokel
- 刊名：Journal of the American Chemical Society
- 出版年：2016
- 出版时间：August 24, 2016
- 年：2016
- 卷：138
- 期：33
- 页码：10571-10577
- 全文大小：421K
- 年卷期：0
- ISSN：1520-5126
文摘
Nine bis(tryptophan) derivatives (BTs) and two control compounds were synthesized and tested for antimicrobial activity against two Escherichia coli strains and a Staphylococcus aureus strain. The effects of linker type, shape, and conformational rigidity were manifested in dramatic differences in altering tetracycline potency when coadministered with that antibiotic. A reversal of resistance was observed for an E. coli strain having a TetA efflux pump. Survival of mammalian cells was assayed with good result.