Synthesis of (Hetero)arylated Pyridazin-3(2H)-ones via Negishi Reaction Involving Zincated Pyridazin-3(2H)-ones

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• 作者：Tom Verhelst ; Zuming Liu ; Jens Maes ; Bert U. W. Maes
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：December 2, 2011
• 年：2011
• 卷：76
• 期：23
• 页码：9648-9659
• 全文大小：426K
• 年卷期：v.76,no.23(December 2, 2011)
• ISSN：1520-6904

文摘

Zincated pyridazin-3(2H)-ones generated via bromine鈥搈agnesium exchange followed by transmetalation using ZnCl₂ or via lactam-directed ortho C4-H zincation with TMPZnCl路LiCl have been synthesized. These in situ created organometallics can be used in Negishi reactions with iodo(hetero)arenes delivering a new approach toward (hetero)arylpyridazin-3(2H)-ones.