Rhodium-Catalyzed Oxidative Amidation of Sterically Hindered Aldehydes and Alcohols

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• 作者：Trang T. Nguyen ; Kami L. Hull
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：December 2, 2016
• 年：2016
• 卷：6
• 期：12
• 页码：8214-8218
• 全文大小：391K
• ISSN：2155-5435

文摘

A rhodium-catalyzed oxidative amidation reaction has been developed with sterically hindered aldehydes and alcohols for the synthesis of amides containing a quaternary carbon at the α position. A variety of amine nucleophiles, both aliphatic and aromatic, are employed and afford the corresponding amides in good to excellent yields. Finally, mechanistic studies are performed to gain insight into both catalytic cycles.