Directed Zincation with TMPZnCl·LiCl and Further Functionalization of the Tropolone Scaffold

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• 作者：Diana Haas ; Daniela Sustac-Roman ; Sophia Schwarz ; Paul Knochel
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：December 16, 2016
• 年：2016
• 卷：18
• 期：24
• 页码：6380-6383
• 全文大小：396K
• ISSN：1523-7052

文摘

The directed zincation of tropolone derivatives was achieved using TMPZnCl·LiCl. Various functionalizations of the zincated intermediates by halogenation, acylation, allylation, and Negishi cross-coupling were successfully performed. Additionally, 1,8-conjugate addition–elimination reactions with a variety of arylmagnesium and secondary alkylzinc reagents were carried out to further elaborate the tropolone core.