Palladium-Catalyzed Double Alkylation of 3-Aryl-2-fluoroallyl Esters with Malonate Nucleophiles through the Carbon–Fluorine Bond Cleavage

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• 作者：Mitsuaki Yamamoto ; Shunsuke Hayashi ; Kazuki Isa ; Motoi Kawatsura
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：February 7, 2014
• 年：2014
• 卷：16
• 期：3
• 页码：700-703
• 全文大小：275K
• ISSN：1523-7052

文摘

The alkylation of (Z)-3-aryl-2-fluoroallyl acetate with the malonate anion by the [Pd(C₃H₅)(cod)]BF₄/2,2鈥?bpy catalyst proceeds through the carbon鈥揻luorine bond cleavage, and 2 equiv of the malonate nucleophile was introduced to the allyl substrate.