Nickel(0)-Catalyzed Cyclization of N-Benzoylaminals for Isoindolinone Synthesis

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• 作者：Danielle M. Shacklady-McAtee ; Srimoyee Dasgupta ; Mary P. Watson
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：July 1, 2011
• 年：2011
• 卷：13
• 期：13
• 页码：3490-3493
• 全文大小：753K
• 年卷期：v.13,no.13(July 1, 2011)
• ISSN：1523-7052

文摘

A nickel(0) catalyst effectively mediates the cyclization of N-benzoyl aminals in the presence of a stoichiometric Lewis acid. This method enables preparation of a variety of isoindolinones with substitution on the benzoyl fragment and C-3 carbon. This reaction likely proceeds via an 伪-amidoalkylnickel(II) intermediate, which then may cyclize via either an electrophilic aromatic substitution or an insertion pathway.