The effects of fumonisin B-glucose reaction products in swine diets was examined. Pigs were feddiets containing 528
mol of total fumonisin B/kg (FB), 528
mol of total FB-glucose adducts/kg(FB-G, 122
mol of unreacted FB/kg), or 0
mol of total FB/kg for 15 days to test the efficacy of theFB-G reaction products in detoxifying FB. Weight gain in FB pigs was lower than in FB-G or controls,which was correlated with feed intake reduction in FB pigs. Serum aspartate aminotransferase,
-glutamyltransferase, and total bilirubin in FB pigs were higher than in FB-G or control pigs. Serumsphinganine/shingosine ratios in FB pigs were higher than in FB-G or control pigs. Microscopicexamination of tissues from FB pigs showed generalized liver necrosis and apoptosis with markedcellular pleomorphism and disorganized hepatic cords. The liver and kidneys in the FB-G groupappeared to be normal. Tissues of controls were free of lesions. Results suggest that dietary FB-Gproducts are less toxic to swine and may provide an detoxification approach in instances of widespreadFB grain contamination (
p < 0.05).Keywords: Fumonisin B; fumonisin B-glucose; detoxification; swine