Isolation and Characterization of Atropisomers of Seven-Membered-Ring Benzolactams

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• 作者：Hidetsugu Tabata ; Naoya Wada ; Yuko Takada ; Tetsuta Oshitari ; Hideyo Takahashi ; Hideaki Natsugari*
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：June 17, 2011
• 年：2011
• 卷：76
• 期：12
• 页码：5123-5131
• 全文大小：933K
• 年卷期：v.76,no.12(June 17, 2011)
• ISSN：1520-6904

文摘

The atropisomeric properties of seven-membered-ring benzolactams (7a鈥?b>c and 8a) [1,5-benzodiazepin-2-one (a), 1,5-benzothiazepin-4-one (b), and 1-benzazepin-2-one (c)] were examined. The atropisomers were isolated as the diastereomers with an (S)-phenethylamide moiety, which were characterized by X-ray crystallography, and the barriers to their interconversion were clarified.