Aerobic Hydroxylation of N-Borylenamine: Triethylborane-Mediated Hydroxyalkylation of α,β-Unsaturated Oxime Ether

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• 作者：Masafumi Ueda ; Hideto Miyabe ; Takahiro Kimura ; Eiko Kondoh ; Takeaki Naito ; Okiko Miyata
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：October 15, 2009
• 年：2009
• 卷：11
• 期：20
• 页码：4632-4635
• 全文大小：190K
• 年卷期：v.11,no.20(October 15, 2009)
• ISSN：1523-7052

文摘

Intermolecular hydroxyalkylation of α,β-unsaturated imines involving Et₃B-mediated regioselective alkyl radical addition and subsequent hydroxylation with molecular oxygen has been developed, in which N-borylenamine generated by trapping of the enaminyl radical with Et₃B was a key intermediate in the proposed aerobic hydroxylation mechanism.