Synthesis of (−)-Chamobtusin A from (+)-Dehydroabietylamine

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• 作者：Naoki Mori ; Kazuma Kuzuya ; Hidenori Watanabe
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：December 2, 2016
• 年：2016
• 卷：81
• 期：23
• 页码：11866-11870
• 全文大小：306K
• ISSN：1520-6904

文摘

Chamobtusin A, a unique diterpene alkaloid isolated from Chamaecyparis obtusa cv. tetragon, is considered to be biosynthesized from an abietane diterpenoid. On the basis of this biosynthetic hypothesis, ferruginol (15) was synthesized from (+)-dehydroabietylamine and then biomimetically transformed into (−)-chamobtusin A in 6 steps (12 steps from (+)-dehydroabietylamine).