A novel series of biaryl amides was identified as ROR纬t inhibitors through core replacement of a starting hit 1. Structure鈥揳ctivity relationship exploration on the biaryl moiety led to discovery of potent ROR纬t inhibitors with good oral bioavailability and CNS penetration. Compounds 9a and 9g demonstrated excellent in vivo efficacy in EAE mice dose dependently with once daily oral administration.