Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe3+ in Cancer Stem Cells

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• 作者：Ruihua Guo ; Shixin Zhou ; Yunchao Li ; Xiaohong Li ; Louzhen Fan ; Nicolas H. Voelcker
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：November 4, 2015
• 年：2015
• 卷：7
• 期：43
• 页码：23958-23966
• 全文大小：628K
• ISSN：1944-8252

文摘

A turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe³⁺ detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 渭M are demonstrated as a Fe³⁺ turn-on fluorescent nanosensor in cancer stem cells. Fe³⁺ binding to such GQDs (RBD-GQDs-Fe³⁺) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.