Anhydride-Additive-Free Nickel-Catalyzed Deoxygenation of Carboxylic Acids to Olefins

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• 作者：Alex John ; Marc A. HillmyerWilliam B. Tolman
• 刊名：Organometallics
• 出版年：2017
• 出版时间：February 13, 2017
• 年：2017
• 卷：36
• 期：3
• 页码：506-509
• 全文大小：267K
• ISSN：1520-6041

文摘

A nickel-catalyzed route for direct, anhydride-additive-free deoxygenation of fatty acids to the corresponding olefins has been developed. The transformation is catalyzed by simple nickel salts of the type NiX₂ (X = halide, acetate, acetylacetonate), uses PPh₃ as a stoichiometric reductant, and exhibits selectivity for generation of linear α-olefin products. The reaction was rendered cocatalytic in PPh₃ using 1,1,3,3-tetramethyldisiloxane (TMDS) as terminal reductant for the in situ reduction of OPPh₃ and catalytic Cu(OTf)₂.