Enantioselective Spirocyclizations from Tryptophanol-Derived Oxazolopiperidone Lactams

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• 作者：Mercedes Amat ; Maria M. M. Santos ; Antonia M. G&oacute ; mez ; Danica Jokic ; Elies Molins ; Joan Bosch
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：July 19, 2007
• 年：2007
• 卷：9
• 期：15
• 页码：2907 - 2910
• 全文大小：96K
• 年卷期：v.9,no.15(July 19, 2007)
• ISSN：1523-7052

文摘

LE>GR ID=ol0712327n00001>ls/orlef7/9/i15/figures/ol0712327n00001.gif" ALIGN="left" HSPACE=5>A straightforward synthetic route to enantiopure spiro[indole-3,3'-indolizidines] is reported. The key step is a Lewis acid promoted cyclizationof a N_a-tosyltryptophanol-derived oxazolopiperidone lactam in the presence of Et₃SiH.