Preparation of Magnetic Microspheres from Water-in-Oil Emulsion Stabilized by Block Copolymer Dispersant
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- 作者：Guojun Liu ; Husheng Yang ; Jiayun Zhou ; Say-Jong Law ; Qingping Jiang ; and Guohan Yang
- 刊名：Biomacromolecules
- 出版年：2005
- 出版时间：May 2005
- 年：2005
- 卷：6
- 期：3
- 页码：1280 - 1288
- 全文大小：490K
- 年卷期：v.6,no.3(May 2005)
- ISSN：1526-4602
文摘
A new method for the preparation of magnetic microspheres is reported. The preparation involved first thedispersion of an aqueous phase, containing magnetite nanoparticles and a water-soluble homopolymer, intodroplets in an organic medium using an amphiphilic block copolymer as the dispersant. This was followedby water distillation at a raised temperature from the aqueous droplets to yield polymer/magnetite particles.The structure of the particles was then locked in by a reagent being added to cross-link the water-solublecopolymer block and homopolymer. Since the hydrophobic block of the copolymer consisted of a protectedpolyester, the removal of the protective moieties from the coronal chains yielded poly(acrylic acid) or otherfunctional polymers to render water dispersibility to the spheres and to enable biomolecule immobilization.