Endothelin-1 expression and alterations of cerebral microcirculation after experimental subarachnoid hemorrhage

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• 作者：Qin Lei (1)
  Shu Li (2)
  Ruibin Zheng (2)
  Ke Xu (2)
  Songbai Li (2)
  
  1. Department of Radiology ; The First Affiliated Hospital of Bengbu Medical College ; Bengbu ; Anhui ; China
  2. The Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province ; Department of Radiology ; The First Affiliated Hospital of China Medical University ; No. 155 Nanjingbei Street ; Heping District ; Shenyang ; 110001 ; Liaoning ; People鈥檚 Republic of China
  
• 关键词：CTP ; Endothelin ; 1 ; SAH ; Vasospasm
• 刊名：Neuroradiology
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：57
• 期：1
• 页码：63-70
• 全文大小：1,214 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neuroradiology
  Imaging and Radiology
  Neurology
  Neurosurgery
  Neurosciences
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1920

文摘

Introduction Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) often leads to poor outcomes in SAH patients. Overexpression of endothelin-1 (ET-1) could contribute to the development of CVS. The purpose of this study was to investigate cerebral microcirculation by whole-brain perfusion CT scan and ET-1 expression following SAH. Methods SAH was induced in rabbits. Cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT) were measured with CT perfusion techniques at days 1, 4, 7, and 14 following SAH. Expression of ET-1 was determined by ELISA accordingly. Histological sections of the brain tissue were also examined. Results Whole-brain perfusion showed that CBV and TTP increased at day 4 and maintained elevated rate until day 14. MTT increased at day 4, peaked at day 7, and then decreased at day 14. CBV of the occipital lobe was greater than that in the frontal and parietal lobes at day 4. CBF of the occipital lobe increased significantly compared to that of other lobes at day 7. ET-1 expression in the SAH group was significantly greater than that in the control at various time points. Moreover, ET-1 levels were positively correlated with MTT value. Conclusion CTP detects changes in cerebral microcirculation following SAH. Microcirculation of each lobe was different and could be quantified to identify high-risk areas of cerebral ischemia. ET-1 expression was significantly increased and was correlated with MTT as well, suggesting that ET-1 influences cerebral microcirculation following SAH.