The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis

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• 作者：Y.H. Lee MD ; PhD (1)
  S.-C. Bae (2)
  
  1. Division of Rheumatology ; Department of Internal Medicine ; Korea University Anam Hospital ; Korea University College of Medicine ; 126-1 ; Anam-dong 5-ga ; Seongbuk-gu ; 136-705 ; Seoul ; Korea
  2. Division of Rheumatology ; Department of Internal Medicine ; The Hospital for Autoimmune Diseases ; Hanyang University Medical Center ; Seoul ; Korea
  
• 关键词：MicroRNAs ; Autoimmune disease ; Inflammatory disease ; Ethnicity ; Polymorphism ; single nucleotide ; Mikro ; RNA ; Autoimmunerkrankung ; Entz眉ndliche Erkrankung ; Ethnizit盲t ; Einzelnukleotidpolymorphismus
• 刊名：Zeitschrift f篓鹿r Rheumatologie
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：74
• 期：2
• 页码：153-156
• 全文大小：295 KB
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• 刊物主题：Internal Medicine; Rheumatology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-1250

文摘

Objective The aim of this study was to explore whether the miR-146a polymorphism (rs2910164) confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). Methods A meta-analysis was conducted on the association of the miR-146a polymorphism with SLE and RA. Results Five studies with 2013聽patients and 2555聽controls were included in the meta-analysis. Meta-analysis revealed no association between SLE and the miR-146a聽G allele (odds ratio, OR聽=鈥?.007, 95鈥? confidence interval, CI聽=鈥?.910鈥?.114, p鈥?鈥?.888). Additionally, no associations were found between the miR-146a polymorphism and SLE using recessive or dominant models, or homozygote contrast. Meta-analysis using allele contrast, recessive and dominant models, as well as homozygote contrast failed to reveal an association between the miR-146a polymorphism and RA (OR for G聽allele聽=鈥?.114, 95鈥?聽CI聽=鈥?.892鈥?.391, p鈥?鈥?.342). Conclusion This meta-analysis demonstrates that the miR-146a polymorphism is not associated with susceptibility to SLE and RA. However, considering the small number of studies, further studies are needed to confirm this result.