Curcumin inhibits placental inflammation to ameliorate LPS-induced adverse pregnancy outcomes in mice via upregulation of phosphorylated Akt

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• 作者：Jianjun Zhou ; Huishuang Miao ; Xiujun Li ; Yali Hu ; Haixiang Sun&#8230
• 关键词：Pregnancy ; Curcumin ; Akt ; Inflammation ; LPS
• 刊名：Inflammation Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：66
• 期：2
• 页码：177-185
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Immunology; Pharmacology/Toxicology; Rheumatology; Allergology; Dermatology; Neurology;
• 出版者：Springer International Publishing
• ISSN：1420-908X
• 卷排序：66

文摘

IntroductionExcessive inflammation results in adverse pregnancy outcomes, including embryonic resorption, fetal growth restriction, and preeclampsia. This study investigated whether curcumin, a highly safe anti-inflammation drug, had protective effect on lipopolysaccharide (LPS)-treated pregnant mice.