New index of pain triggered by spinal activation of voltage-dependent sodium channels

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• 作者：Ryugo Enomoto (1)
  Mina Tsukamoto (1)
  Yukinori Shimoshige (1)
  Toshiaki Aoki (1)
  Nobuya Matsuoka (1)
  
• 关键词：Veratridine ; Nociceptive responses ; Sodium channel blocker ; Morphine ; Pregabalin
• 刊名：Journal of Anesthesia
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：27
• 期：6
• 页码：939-941
• 全文大小：
• 作者单位：Ryugo Enomoto (1)
  Mina Tsukamoto (1)
  Yukinori Shimoshige (1)
  Toshiaki Aoki (1)
  Nobuya Matsuoka (1)
  
  1. Pharmacology Research Laboratories, Astellas Pharma Inc., Miyukigaoka 21, Tsukuba, Ibaraki, 305-8585, Japan
  
• ISSN：1438-8359

文摘

Voltage-dependent sodium channels (VDSCs) are crucial for pain generation. Here, to develop a new behavioral index of pain induced by spinal VDSC activation, we examined whether intrathecal veratridine injection produced nociceptive behavior. Intrathecal injection of the VDSC opener veratridine in mice dose-dependently induced nociceptive responses, with response times subsequently reduced by administration of morphine or pregabalin. Systemic administration of lidocaine and mexiletine, but not amitriptyline, also decreased this response time. Taken together, these results demonstrated that response time of nociceptive behavior induced by intrathecal veratridine injection is a quantitative index of pain triggered by spinal VDSC activation.