5-HT₂ receptor mechanisms of the dorsal periaqueductal gray in the conditioned and unconditioned fear in rats

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• 作者：Luciana Chrystine Oliveira ; Ana Carolina Broiz ; Carlos Eduardo de Macedo ; J. Landeira-Fernandez and Marcus Lira Brand?o
• 关键词：5 ; HT receptors ; Dorsal periaqueductal gray ; Ketanserin ; α ; methyl ; 5 ; HT ; Unconditioned fear ; Contextual fear conditioning
• 刊名：Psychopharmacology
• 出版年：2007
• 出版时间：April, 2007
• 年：2007
• 卷：191
• 期：2
• 页码：253-262
• 全文大小：303 KB

文摘

Rationale It is well known that 5-HT₂ mechanisms modulate the defensive behavior produced by the stimulation of the dorsal periaqueductal gray (dPAG). However, in spite of the notion that past stressful experiences play a role in certain types of anxiety, only studies with the stimulation of the dPAG of rats without previous aversive experience have been conducted so far.