Direct asymmetric aldol reaction of acetophenones with aromatic aldehydes catalyzed by chiral Al/Zn heterobimetallic compounds

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• 作者：Xiao Li ; Lei Zhang ; Yu-Hua Xiao ; Qi-Peng Guo…
• 关键词：asymmetric synthesis ; asymmetric catalysis ; heterobimetallics ; aldol reaction ; aryl aldehydes
• 刊名：Russian Journal of General Chemistry
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：86
• 期：8
• 页码：1922-1930
• 全文大小：274 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chemistry
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3350
• 卷排序：86

文摘

Chiral Al/Zn heterobimetallic complexes are effective catalysts for the direct highly enantioselective aldol reaction of acetophenones with aromatic aldehydes. The Al site in the complex acts as a Lewis acid to activate aldehyde, whereas ethylzinc alkoxide plays a role of a Brønsted base to form a reactive zinc enolate with acetophenone. Distinct nature of two different metals contributes to the efficient direct asymmetric aldol reaction.